Fresh analysis indicates that individuals who come off popular GLP-1 drugs like semaglutide or tirzepatide can put back on shed pounds much more quickly than those who end traditional lifestyle plans.
Research printed in a prominent health publication shows that while overweight people often shed a large proportion of their total mass while using the jabs, the mass returns at an average rate of nearly a kilo each month after stopping.
"Individuals using such treatments need to be informed of the risk of quick rebound weight gain when the medication is stopped," stated expert Dr. Susan Jebb.
Such speed of recovery suggests a reversion to starting weight within about 18 months.
Comparing Therapies
The study, which reviewed 37 of trials involving thousands of participants, compared the results of the injectable medications with older methods.
Scientists note that people who shed pounds through lifestyle changes alone typically experience a less rapid creep back—around 0.1 kg a month—post-intervention.
Explaining the Quick Rebound
Doctors believe the mode of action of the drugs accounts for the amplified regain.
GLP-1 drugs imitate a body's own chemical called GLP-1, which moderates feelings of fullness.
"Long-term administration of GLP-1 concentrations far above than the body's typical production may cause the body to generate a reduced amount of its own natural GLP-1, and may also lessen sensitivity to its actions," said Dr. Adam Collins, a nutrition specialist.
"Discontinuation of this GLP-1 'fix' leads to hunger is no longer kept in check, making overeating much more probable."
A Lifelong Condition?
Health authorities recommend the injections for people with weight-linked medical conditions, alongside prescribed lifestyle changes.
Many experts say that, considering the significant potential of relapse, the treatment should be considered life-long.
This view is supported by pharmaceutical companies, who say that the results "underscore the persistent character of excess weight," akin to managing conditions like hypertension.
User Accounts
Users who have discontinued the medication report a intense return of hunger.
"It felt as if a trigger activating and you become extremely hungry," said a patient.
The struggle is worsened if patients have not adopted lasting dietary or behavioural modifications during treatment.
Growing Interest
Figures indicate that a significant number of adults in the UK have used weight-loss jabs in the last 12 months, with demand being substantial.
- Adoption is greater among females compared to males.
- The middle-aged demographic shows the greatest usage rates.
- Many access the medications through private healthcare rather than public health services.
In conclusion, experts caution that while the jabs are potent agents for shedding pounds, they are not a standalone fix and lasting health benefits relies on combined lifestyle changes.
